論文情報Publications

新着論文

  • "The Characteristics of Patients with Severe COVID-19 Pneumonia Treated with Direct Hemoperfusion Using Polymyxin B-Immobilized Fiber Column (PMX-DHP)." Kuwana T et al. Infect Drug Resist (2022) 15:4819-28

    PubMed
  • "Endotoxin removal therapy with Polymyxin B immobilized fiber column as a COVID-19- bedside strategy protocol for endotoxic shock." De Rosa S et al. Front Nephrol (Aug 3, 2022 online)

  • "Endotoxemic Sepsis: Clinical Features and Therapy." Kellum JA et al. J Transl Crit Care Med (2022) 4:13

  • "Potential survival benefit and early recovery from organ dysfunction with polymyxin B hemoperfusion: perspectives from a real-world big data analysis and the supporting mechanisms of action." Shoji H et al. J Anesth Analg Crit Care (2022) 2:27

  • "Polymyxin B Hemoperfusion in Pediatric Septic Shock: Single-Center Observational Case Series." Saetang P et al. Pediatr Crit Care Med (2022) 23:e386-e391

    PubMed
  • "Polymyxin B Hemoperfusion in Septic Shock: Finding the Right Patients by Analyzing Real-World Big Data." Ishikura H. Blood Purif (Jun 2, 2022 online)

    PubMed
  • "For safe and adequate blood purification therapy in severe COVID-19 ‒ what we have learned so far." Katagiri D et al. Global Health Med (2022) 4:94-100

  • "When should PMX-DHP be introduced to improve COVID-19 prognosis?" Katagiri D et al. Ther Apher Dial (2022) 26:550-1

    PubMed
  • "The Rationale and Current Status of Endotoxin Adsorption in the Treatment of Septic Shock." Śmiechowicz J et al. J Clin Med (2022) 11:619

    PubMed
  • "Impact of polymyxin B hemoperfusion therapy on high endotoxin activity level patients after successful infection source control: a prospective cohort study." Lee WY et al. Sci Rep (2021) 11:24132

    PubMed
  • "Polymyxin B and low-dose hydrocortisone treatment in a patient with uroseptic shock in a rural health unit." Arai T et al. Oxf Med Case Reports (2021) 11:433-5

    PubMed
  • "Effectiveness of polymyxin B hemoperfusion for sepsis depends on the baseline SOFA score: a nationwide observational study." Fujimori K et al. Ann Intensive Care (2021) 11:141

    PubMed
  • "Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants with Septic Shock. Is Extended Duration Better than Early Start? Comment to the Letter to the Editor of Nishizaki and Colleagues" Mitaka C et al. Blood Purif (2022) 51:475-6

    PubMed
  • "Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion for Micro-Preemie Infants: Is Extended Duration Better than Early Start?" Nishizaki N et al. Blood Purif (2022) 51:472-4

    PubMed
  • "Acute respiratory distress syndrome caused by carbon monoxide poisoning and inhalation injury recovered after extracorporeal membrane oxygenation along with direct hemoperfusion with polymyxin B-immobilized fiber column: a case report." Jang JH et al. J Med Case Rep (2021) 15:456

    PubMed
  • "Endotoxin and Cytokine Sequential Hemoadsorption in Septic Shock and Multi-Organ Failure." Ruiz-Rodríguez JC. Blood Purif (2022) 51:630-3

    PubMed
  • "Polymyxin B hemoperfusion in septic patients with acute myeloblastic and premyelocytic leukemia" De Simone L et al. Case Rep Int (2021) 10:100094Z06LS2021

  • "Studying polymyxin B-immobilized hemoperfusion therapy to remove endotoxin in infection with GN bacteria has conflicting results: We are not sure!" Honore PM H et al. J Crit Care (2021) 65:228-9

    PubMed
  • "Possibility of PMX-DHP therapy as a principal strategy against cytokine storm in COVID-19: Insights from reconstructed coagulation data." Ogawa H et al. J Clin Apher (2021) 36:785-6

    PubMed
  • "Is Exchange Transfusion for Severe Neonatal Infection Preferable to Polymyxin B-immobilized Fiber Column for Direct Hemoperfusion: Pros and Cons." Nishizaki N et al. Tohoku J Exp Med (2021) 254:141-2

    PubMed
  • "Whole Blood Gene Expression Profiling in Response to Treatment for Septic Shock: A Case Report." Akitomi S et al. Ann Clin Med Case Rep (2021) V6(17):1-5

  • "Impact of Extended Duration of Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion on Hemodynamics, Vasoactive Substance Requirement, and Pulmonary Oxygenation in Patients with Sepsis: An Observational Study." Mitaka C et al. Blood Purif (2022) 51:62-9

    PubMed
  • "Unsatisfactory Short-Term Neurodevelopmental Outcomes of Preterm Infants Who Received Polymyxin B-Immobilized Fiber Column-Direct Hemoperfusion for Septic Shock." Nishizaki N et al. Tohoku J. Exp. Med (2021) 253:275-81

    PubMed
  • "Effects of Polymyxin B Hemoperfusion in Patients with Sepsis Requiring Continuous Hemodiafiltration: Analysis of a Nationwide Administrative Database in Japan." Fujimori K et al. Ther Apher Dial (2021) 25:384-9

    PubMed
  • "Polymyxin B hemoperfusion therapy and extracorporeal CO2 removal in a patient with COVID-19: A case report." Luca M et al. Case Rep Int (2021) 10:100093Z06ML2021.

  • "Endotoxin Adsorbent Therapy in Severe COVID-19 Pneumonia." Peerapornratana S et al. Blood Purif (2022) 51:47-54

    PubMed
  • "Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock." Mitaka C et al. Acute Crit Care (2021) 36:85-91

    PubMed
  • "PMX-DHP Therapy for Dyspnea and Deoxygenation in Severe COVID-19 Pneumonia: A Case Series." Kuwana T et al. Infect Drug Resist (2021) 14:1305-10

    PubMed
  • "Multimodality treatment in immunocompromised patients with severe COVID-19: the role of IL-6 inhibitor, intravenous immunoglobulin, and haemoperfusion." Leelayuwatanakul N et al. Respirol Case Rep (2021) 9:e0733 

    PubMed
  • "Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock." Shoji H et al. Int J Mol Sci (2021) 22:2228

    PubMed
  • "Uncertain Clinical Effect of Polymyxin B Hemoperfusion in Patients with Septic Acute Kidney Injury Requiring Continuous Renal Replacement Therapy." Lee JM et al. Shock (2021) 56:551-6

    PubMed
  • "Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan."Fujimori K et al. Blood Purification (2021) 50:560-5

    PubMed
  • "Tocilizumab and PMX-DHP have efficacy for severe COVID-19 pneumonia." Shimoyama S et al. SAGE Open Medical Case Rep (2021) 9:1-5

    PubMed

主要論文

  • "Effectiveness of polymyxin B hemoperfusion for sepsis depends on the baseline SOFA score: a nationwide observational study."Fujimori K et al. Ann Intensive Care (2021) 11:141

    PubMed
  • "Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan."Fujimori K et al. Blood Purification (2021) 50:560-5 

    PubMed
  • "Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial." Chen SH et al. (2020) Ann Intensive Care 10:80

    PubMed
  • "Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial." Klein DJ et al. Intensive Care Med (2018) Nov. 23

    PubMed
  • "The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients." Srisawat N et al. Crit Care (2018) 22:279

    PubMed
  • "Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial.." Dellinger RP et al. JAMA (2018) 320:1455-63

    PubMed
  • "Polymyxin B-immobilized hemoperfusion and mortality in critically ill adult patients with sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis." Fujii T et al. Intensive Care Med (2018) 44:167-78

    PubMed
  • "Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study." Nakamura Y et al. Crit Care (2017) 21:134

    PubMed
  • "Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis." Chang T et al. Crit Care Med (2017) 45:e858-e864

    PubMed
  • "Polymyxin B Hemoperfusion for Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. "Terayama T et al. Surg Infect (2017) 18:225-33

    PubMed
  • "Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry." Cutuli SL et al. Ann Intensive Care (2016) 6:77

    PubMed
  • "Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis." Iwagami M et al. Blood Purif (2016) 42:9-17

    PubMed
  • "Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial." Payen D et al. Intensive Care Med (2015) 41:975-84

    PubMed
  • "Rescue therapy with Polymyxin B hemoperfusion in high dose vasopressor therapy Refractory Septic Shock." Monti G et al. Minerva Anestesiol (2015) 81:516-2

    PubMed
  • "Endotoxin adsorption using polymyxin B immobilized fiber cartridges in severe sepsis patients following cardiac surgery." Yaroustovsky M et al. Int J Artif Organs (2014) 37:299-307

    PubMed
  • "Postoperative Polymyxin B Hemoperfusion and Mortality in Patients With Abdominal Septic Shock: A Propensity-Matched Analysis." Iwagami M et al. Crit Care Med (2013) 42:1187-93

    PubMed
  • "Blood Purification and Mortality in Sepsis:A Meta-analysis of Randomized Trials." Zhou F et al. Crit Care Med (2013) 41:2209-2220

    PubMed
  • "Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial." Cruz DN et al. JAMA (2009) 301:2445-52

    PubMed
  • "Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors." Cantaluppi V et al. Intensive Care Med (2008) 34:1638-45

    PubMed
  • "Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review." Cruz DN et al. Crit Care (2007) 11:R47

    PubMed
  • "A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal Infection." Vincent JL et al. Shock (2005) 23:400-5

    PubMed

総説

  • "Potential survival benefit and early recovery from organ dysfunction with polymyxin B hemoperfusion: perspectives from a real-world big data analysis and the supporting mechanisms of action." Shoji H et al. J Anesth Analg Crit Care (2022) 2:27

  • “Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock.” Mitaka C et al. Acute Crit Care (2021) 36:85-91

    PubMed
  • "Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock." Shoji H et al. Int J Mol Sci (2021) 22:2228

    PubMed
  • "Evidence and Perspectives on the Use of Polymyxin B-Immobilized Fiber Column Hemoperfusion among Critically Ill Patients." Yamashita C et al. Contrib Nephrol (2018) 196:215-22

    PubMed
  • "History and current status of polymyxin B-immobilized fiber column for treatment of severe sepsis and septic shock" Shimizu T et al. Ann Gastroenterol Surg (2017) 2017:1–9

    PubMed
  • "Polymyxin B hemoperfusion: a mechanistic perspective." Ronco C et al. Crit Care (2014) 18:309

    PubMed
  • "Immunomodulation in Sepsis: The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge." Esteban E et al. Mediators Inflamm (2013) 2013:507539

    PubMed
  • 「海外におけるポリミキシンB固定化繊維カラムの臨床応用の現状,および研究の今後の進むべき方向」小路久敬 日本集中治療医学会誌(2012)3:109-16
  • 「血中エンドトキシン除去カラム(PMX)の有用性と意義の確立に向けた多角的アプローチ」小路久敬 日本アフェレシス学会雑誌(2012)31:109-17