Publications

New Publications

  • Case Series

    "Polymyxin B hemoperfusion in septic patients with acute myeloblastic and premyelocytic leukemia" De Simone L et al. Case Rep Int (2021) 10:100094Z06LS2021

  • Letter

    "Studying polymyxin B-immobilized hemoperfusion therapy to remove endotoxin in infection with GN bacteria has conflicting results: We are not sure!" Honore PM H et al. J Crit Care (Jul 9, 2021 online)

    PubMed
  • Letter

    "Possibility of PMX-DHP therapy as a principal strategy against cytokine storm in COVID-19: Insights from reconstructed coagulation data." Ogawa H et al. J Clin Apher (Jul 12, 2021 online)

    PubMed
  • Case Report

    "Is Exchange Transfusion for Severe Neonatal Infection Preferable to Polymyxin B-immobilized Fiber Column for Direct Hemoperfusion: Pros and Cons." Nishizaki N et al. Tohoku J Exp Med (2021) 254:141-2

    PubMed
  • Case Report

    "Whole Blood Gene Expression Profiling in Response to Treatment for Septic Shock: A Case Report." Akitomi S et al. Ann Clin Med Case Rep (2021) V6(17):1-5

  • Observational Study

    "Impact of Extended Duration of Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion on Hemodynamics, Vasoactive Substance Requirement, and Pulmonary Oxygenation in Patients with Sepsis: An Observational Study." Mitaka C et al. Blood Purif (Apr 28, 2021 online)

    PubMed
  • Observational Study

    "Unsatisfactory Short-Term Neurodevelopmental Outcomes of Preterm Infants Who Received Polymyxin B-Immobilized Fiber Column-Direct Hemoperfusion for Septic Shock." Nishizaki N et al. Tohoku J. Exp. Med (2021) 253:275-81

    PubMed
  • Observational Study

    "Effects of Polymyxin B Hemoperfusion in Patients with Sepsis Requiring Continuous Hemodiafiltration: Analysis of a Nationwide Administrative Database in Japan." Fujimori K et al. Ther Apher Dial (2021) 25:384-9

    PubMed
  • Case Report

    "Polymyxin B hemoperfusion therapy and extracorporeal CO2 removal in a patient with COVID-19: A case report." Luca M et al. Case Rep Int (2021) 10:100093Z06ML2021.

  • Case Series

    "Endotoxin Adsorbent Therapy in Severe COVID-19 Pneumonia." Peerapornratana S et al. Blood Purif (Apr 15, 2021 online)

    PubMed
  • Review

    "Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock." Mitaka C et al. Acute Crit Care (2021) 36:85-91

    PubMed
  • Case Series

    "PMX-DHP Therapy for Dyspnea and Deoxygenation in Severe COVID-19 Pneumonia: A Case Series." Kuwana T et al. Infect Drug Resist (2021) 14:1305-10

    PubMed
  • Case Series

    "Multimodality treatment in immunocompromised patients with severe COVID-19: the role of IL-6 inhibitor, intravenous immunoglobulin, and haemoperfusion." Leelayuwatanakul N et al. Respirol Case Rep (2021) 9:e0733 

    PubMed
  • Review

    "Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock." Shoji H et al. Int J Mol Sci (2021) 22:2228

    PubMed
  • Observational Study

    "Uncertain Clinical Effect of Polymyxin B Hemoperfusion in Patients with Septic Acute Kidney Injury Requiring Continuous Renal Replacement Therapy." Lee JM et al. Shock (Feb 17, 2021 online)

    PubMed
  • Observational Study

    "Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan."Fujimori K et al. Blood Purification (2021) 50:560-5 

    PubMed
  • Case Series

    "Tocilizumab and PMX-DHP have efficacy for severe COVID-19 pneumonia." Shimoyama S et al. SAGE Open Medical Case Rep (2021) 9:1-5

    PubMed
  • Case Series

    "Polymyxin B hemoperfusion in COVID‐19 Patients with endotoxic shock: Case Series from EUPHAS II registry." De Rosa S et al. Artif Organs (2021) 45:E187-94

    PubMed
  • Case Report

    "Case Report: Successful Use of Extracorporeal Therapies After ECMO Resuscitation in a Pediatric Kidney Transplant Recipient." Rybalko A et al. Front Pediatr (2020) 8:593123

    PubMed
  • Case Series

    "Direct hemoperfusion using a polymyxin B-immobilized polystyrene column for COVID-19." Katagiri D et al. J Clin Apher (2021) 36:313-21

    PubMed
  • In vitro Study

    "In Vitro Comparison of the Endotoxin Adsorption by Blood Purification Devices." Shukevich D et al. Ther Apher Dial (Nov 2, 2020 online)

    PubMed
  • Observational Study

    "Selective Polymyxin Hemoperfusion in Complex Therapy of Sepsis in Children after Cardiac Surgery." Yaroustovsky M et al. Blood Purif (2021) 50:222-9

    PubMed
  • Case Report

    "Damage Control Management of Perforating Pyometra Presenting with Septic Shock after the Return of Spontaneous Circulation." Takamatsu J et al. Case Rep Med (2020) 2020:8545232

    PubMed
  • Case Report

    "Polymyxin B haemoperfusion treatment for respiratory failure and hyperferritinaemia due to COVID‐19." Ishiwari M et al. Respirol Case Rep (2020) 8:e00679

    PubMed
  • Systematic Review

    "Effect of Extracorporeal Blood Purification on Mortality in Sepsis: A Meta-Analysis and Trial Sequential Analysis." Show TAC et al. Blood Purif (2021) 50:462-72

    PubMed
  • Case Report

    "Continuous extracorporeal treatments in a dialysis patient with COVID-19." Nihei Y et al. CEN Case Rep (2021) 10:172-7

    PubMed
  • Letter

    "Adjunctive therapies for early withdrawal from extracorporeal membrane oxygenation." Ogawa H et al. J Cardiac Surg (2020) 35:3671-2

    PubMed
  • Systematic Review

    "Effectiveness of polymyxin B-immobilized hemoperfusion against sepsis and septic shock: A systematic review and meta-analysis." Li X et al. J Crit Care (2021) 63:187-95

    PubMed
  • In vitro Experiment

    "Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study." Utsunomiya Y et al. Blood Purif (2021) 50:230-7

    PubMed
  • Case Report

    "Successful Recovery from COVID-19-associated Acute Respiratory Failure with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion." Kusaba Y et al. Intern Med (2020) 59:2405-08

    PubMed
  • Case Report

    "Treatment of Pyonephritis Complicated by Septic Shock Using Extracorporeal Device Polymyxin B-Hemoperfusion." Amoruso G et al. Blood Purif (2020) 49:627-30

    PubMed
  • Case Report

    "Intensive care management of a patient with necrotizing fasciitis due to non-O1/O139 Vibrio cholerae after traveling to Taiwan: a case report." Tsuruta K et al. BMC Infectious Diseases (2020) 20:618

    PubMed
  • Case Report

    "Severe Sepsis Caused by Bacteria That Entered via the Intestinal Tract: A Case of Crohn's Disease in a Child." Satoh K et al. Cureus (2020) 12:e9822

    PubMed
  • Case Report

    "A case of successful treatment of severe COVID-19 pneumonia with favipiravir and tocilizumab in post–kidney transplant recipient." Thammathiwat et al. Transpl Infect Dis (2020) 00:e13388

    PubMed
  • Observational Study

    "Initial Experience of Using Polymyxin B Hemoperfusion in Abdominal Septic Shock: Things to Consider for Better Outcome." Park YJ et al. J Acute Care Surg (2020) 10:13-7

  • RCT

    "Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial." Chen SH et al. (2020) Ann Intensive Care 10:80

    PubMed
  • Observational Study

    "Lactate predicts the 28-day survival rate in patients with septic shock treated with the combination of PMX-DHP and rTM." Yamato M et al. Ther Apher Dial (2020) 24:492-8

    PubMed
  • Observational Study

    "Beneficial Effect Modification on Survival Outcome of Sepsis Between ART-123 and Polymyxin B‑immobilised Haemoperfusion: A Nationwide Japanese Registry Study." Mochizuki K et al. Ann Intensive Care (2020) 10:57

    PubMed
  • Case Report

    "Septicemia, Necrotizing Fasciitis, and Peritonitis Due to Vibrio Vulnificus Treated With Early Use of Polymyxin B Hemoperfusion in a Patient Undergoing CAPD: A Case Report." Kim JY et al. BMC Nephrol (2020) 21:127

    PubMed
  • RCT sub-analysis

    "Importance of Endotoxin Clearance in Endotoxemic Septic Shock: An Analysis From the Evaluating Use of PolymyxinB Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemic Septic Shock (EUPHRATES) Trial." Rachoin JS et al. Crit Care Expl (2020) 2:e0083 

    PubMed
  • Case Report

    "Successful treatment of direct hemoperfusion with polymyxin B immobilized fiber for septic shock and severe acute kidney injury due to ceftriaxone-resistant Escherichia coli: a case report with literature review." Shima H et al. Renal Replacement Ther (2020) 6:16

  • Observational Study

    "Identifying Septic Shock Populations Benefitting from Polymyxin B Hemoperfusion: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model." Nakata H et al. Shock (2020) 54:667-74

    PubMed
  • Case Series

    "Clinical effects of polymyxin B-immobilized fiber column direct hemoperfusion for severe bacterial meningitis: A series of 10 cases." Suzuki Y et al. Clin Case Rep (2020) 8:823-32

    PubMed
  • Editorial

    "Could There Be a Biologically Plausible Niche for Polymyxin B-Immobilized Fiber Column Direct Hemoperfusion Treatment in Early Onset Neonatal Septic Shock?" Aldewereld Z et al. Pediatr Crit Care Med (2020) 21:202-3

    PubMed
  • Case Report

    "Sequential Extracorporeal Therapy Collaborative Device and Timely Support for Endotoxic, Septic, and Cardiac Shock: A Case Report."
    De Rosa S et al. Blood Purif (2020) 49:502-98

    PubMed
  • Observational Study

    "Polymyxin B hemoperfusion as a feasible therapy after source control in abdominal septic shock."
    Kim JJ et al. World J Gastrointest Surg (2019) 11:422-32

    PubMed
  • Meta Analysis

    "Effect of polymyxin B hemoperfusion on the outcome of patients with sepsis and septic shock."Lin WT et al.J Infect (2020) 80:350-71

    PubMed

Key Publications

  • Observational Study

    "Effects of Polymyxin B Hemoperfusion on Septic Shock Patients Requiring Noradrenaline: Analysis of a Nationwide Administrative Database in Japan."Fujimori K et al. Blood Purification (Feb 12, 2021 online)  

    PubMed
  • RCT

    "Effects of endotoxin adsorber hemoperfusion on sublingual microcirculation in patients with septic shock: a randomized controlled trial." Chen SH et al. (2020) Ann Intensive Care 10:80

    PubMed
  • RCT

    "Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial."
    Klein DJ et al. Intensive Care Med (2018) Nov. 23

    PubMed
  • RCT

    "The effect of polymyxin B hemoperfusion on modulation of human leukocyte antigen DR in severe sepsis patients."
    Srisawat N et al. Crit Care (2018) 22:279

    PubMed
  • RCT

    "Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial.."
    Dellinger RP et al. JAMA (2018) 320:1455-63

    PubMed
  • Systematic Review

    "Polymyxin B-immobilized hemoperfusion and mortality in critically ill adult patients with sepsis/septic shock: a systematic review with meta-analysis and trial sequential analysis."
    Fujii T et al. Intensive Care Med (2018) 44:167-78

    PubMed
  • Observational Study

    "Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study."
    Nakamura Y et al. Crit Care (2017) 21:134

    PubMed
  • Systematic Review

    "Effects of Polymyxin B Hemoperfusion on Mortality in Patients With Severe Sepsis and Septic Shock: A Systemic Review, Meta-Analysis Update, and Disease Severity Subgroup Meta-Analysis."
    Chang T et al. Crit Care Med (2017) 45:e858-e864

    PubMed
  • Systematic Review

    "Polymyxin B Hemoperfusion for Sepsis and Septic Shock: A Systematic Review and Meta-Analysis."
    Terayama T et al. Surg Infect (2017) 18:225-33

    PubMed
  • Observational Study

    "Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry."
    Cutuli SL et al. Ann Intensive Care (2016) 6:77

    PubMed
  • Observational Study

    "Potential Survival Benefit of Polymyxin B Hemoperfusion in Septic Shock Patients on Continuous Renal Replacement Therapy: A Propensity-Matched Analysis."
    Iwagami M et al. Blood Purif (2016) 42:9-17

    PubMed
  • RCT

    "Early use of polymyxin B hemoperfusion in patients with septic shock due to peritonitis: a multicenter randomized control trial."
    Payen D et al. Intensive Care Med (2015) 41:975-84

    PubMed
  • Observational Study

    "Rescue therapy with Polymyxin B hemoperfusion in high dose vasopressor therapy Refractory Septic Shock."
    Monti G et al. Minerva Anestesiol (2015) 81:516-2

    PubMed
  • Observational Study

    "Endotoxin adsorption using polymyxin B immobilized fiber cartridges in severe sepsis patients following cardiac surgery."
    Yaroustovsky M et al. Int J Artif Organs (2014) 37:299-307

    PubMed
  • Observational Study

    "Postoperative Polymyxin B Hemoperfusion and Mortality in Patients With Abdominal Septic Shock: A Propensity-Matched Analysis."
    Iwagami M et al. Crit Care Med (2013) 42:1187-93

    PubMed
  • Systematic Review

    "Blood Purification and Mortality in Sepsis:A Meta-analysis of Randomized Trials."
    Zhou F et al. Crit Care Med (2013) 41:2209-2220

    PubMed
  • RCT

    "Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial."
    Cruz DN et al. JAMA (2009) 301:2445-52

    PubMed
  • RCT

    "Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors."
    Cantaluppi V et al. Intensive Care Med (2008) 34:1638-45

    PubMed
  • Systematic Review

    "Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review."
    Cruz DN et al. Crit Care (2007) 11:R47

    PubMed
  • RCT

    "A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal Infection."
    Vincent JL et al. Shock (2005) 23:400-5

    PubMed

Reviews

  • Review

    "Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock." Mitaka C et al. Acute Crit Care (2021) 36:85-91 

    PubMed
  • Review

    "Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock." Shoji H et al. Int J Mol Sci (2021) 22:2228

    PubMed
  • Review

    "Evidence and Perspectives on the Use of Polymyxin B-Immobilized Fiber Column Hemoperfusion among Critically Ill Patients."
    Yamashita C et al. Contrib Nephrol (2018) 196:215-22

    PubMed
  • Review

    "History and current status of polymyxin B-immobilized fiber column for treatment of severe sepsis and septic shock"
    Shimizu T et al. Ann Gastroenterol Surg (2017) 2017:1–9

    PubMed
  • Review

    "Polymyxin B hemoperfusion: a mechanistic perspective."
    Ronco C et al. Crit Care (2014) 18:309

    PubMed
  • Review

    "Immunomodulation in Sepsis: The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge."
    Esteban E et al. Mediators Inflamm (2013) 2013:507539

    PubMed

List of Publications